Missionaries entered Nepal probably in 1715, when Capuchin fathers entered the Kathmandu Valley at the invitation of the Malla Kings. Father Sharma Anthony Francis, who has headed the Catholic mission and then prefecture since 1983, has stated, "The priests were given full authority to preach Christianity and even build a church, called Our Lady's Assumption, somewhere in Lalitpur District".

In the early years, from 1951 till 1990 the church has grown relatively slow .

In 1990 the democratic system in Nepal changed and since then every Nepali citizen is allowed to caste his or her vote with elections for the government.

Although it is not sure why and how, but since 1990 the growth of the number of Christians has accelerated tremendously. Up to today the Christian Church in Nepal is one of the fastest growing churches in the world.